Sunscreens and cosmetics containing titanium dioxide are generally considered safe since they are mineral-based products. Mineral products are often recommended for acne-prone and sensitive skin. However, there have been some concerns that titanium dioxide may have a negative impact on health.

In a 2016 study published in Scientifica (Cairo), Egyptian researchers examined the effects of titanium dioxide nanoparticles on the organs of mice by orally administering the food additive daily, for five days. The results showed that the exposure produced “mild to moderate changes in the cytoarchitecture of brain tissue in a time dependent manner.” Furthermore, “Comet assay revealed the apoptotic DNA fragmentation, while PCR-SSCP pattern and direct sequencing showed point mutation of Presenilin 1 gene at exon 5, gene linked to inherited forms of Alzheimer’s disease.” The researchers wrote: “From these findings, “the present study concluded that TiO2NPs is genotoxic and mutagenic to brain tissue which in turn might lead to Alzheimer’s disease incidence.”

2.Inorganic white pigment. Widely used as a white pigment for plastics, paints and inks such as polyolefins, vinyl resins, ABS resins, polystyrene, polycarbonate, nylon and polyoxymethylene.